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(558) Plasma Brain Natriuretic Peptide as a Biochemical Marker in Pulmonary Embolism?


Shikha Tandon, n/a

Shikha Tandon, n/a


Background and Objectives: Brain natriuretic peptide (BNP) is a neurohormone secreted from cardiac ventricles in response to ventricular strain which is known to correlate closely with the pressure and mural tension of the right ventricle and with pulmonary arterial pressure. BNP is found to be higher in acute pulmonary embolism (APE) but the increase in mortality and morbidity as well as its prognostic value remains undefined.

Methods: Plasma BNP levels were measured among the 70 consecutive patients arriving at the emergency department with shortness of breath and moderate to high probability of pulmonary embolism. The clinical and physical screening followed by 12 lead electrocardiography, chest X-ray, echocardiography, laboratory tests including complete blood count, coagulation profile, renal and liver functions, brain natriuretic peptide and multiline computed tomography were performed in all the subjects.

Results: 56 patients were diagnosed with APE. Out of 56 subjects, 24 subjects were diagnosed with massive embolism while 32 patients had mild to moderate embolism. Among the first group 16 patients died while only 6 patients from the second group died. BNP levels were significantly higher in subjects with massive embolism (162.8 ± 22.32 pg/ml) compared to subjects with mild to moderate embolism (93.4 ± 11.2 pg/ml) (P < 0.001).

Conclusion: The role of plasma BNP levels is promising and could be used as a possible prognostic marker in patients with pulmonary embolism.

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