Tsetse flies (Diptera: Glossinidae) are the sole cyclical vectors of trypanosome pathogens causing African trypanosomosis. The public health and economic importance of these flies, and limitations of available control methods necessitate development of new vector control tools. Recent advances employ repellents from non-preferred hosts to minimize vector-host contacts. For example, a four-component potent repellent blend (WRC) identified from waterbuck skin odors. However, the composition of WRC changes over time due to photo-oxidation. It is therefore important to explore and exploit skin-derived odors of other non-preferred hosts to identify more stable repellents for tsetse fly control. Here, we show that crude skin odors of the non-preferred host zebra reduced captures of the savannah tsetse fly Glossina pallidipes by ~ 67%. Gas chromatography-electroantennographic detection (GC-EAD) and GC-mass spectrometry identified seven physiologically-active components; four aldehydes (heptanal, octanal, nonanal and decanal) and three ketones (6-methyl-5-hepten-2-one, acetophenone and geranyl acetone) in zebra skin odors. In field assays, the blend of three ketones and geranyl acetone alone accounted for the observed repellency of the crude skin odors against G. pallidipes. A similar repellent effect was found for the ketone blend and geranyl acetone alone against the riverine tsetse fly G. fuscipes fuscipes, which compared favorably with the WRC. Our results indicate that geranyl acetone is an effective component for use in the integrated control of savannah and riverine tsetse flies.