(PM P34) Influence of Older Age on the Prognosis after CRS+HIPEC for Peritoneal Carcinomatosis of Appendiceal Origin

Purposes Peritoneal carcinomatosis (PC) of appendiceal origin is the most suitable disease entity for CRS+HIPEC. Some cases show less aggressive biological behavior, and even extensive PC can be candidate in such cases. While number of elderly patients is increasing, indication for elderly patients remains controversial. Materials and methods: Data of 52 consecutive cases with PC of appendiceal origin undergoing CRS+HIPEC were analyzed. Older age was defined as >70 years old.

Results: There were 20 patients with age>70. PCI was 32 (15-39) and 28 (3-39) in the groups with age>70 and <70, respectively. CC-0/1 was achieved in 15 out of 20 patients with age>70 and 28 out of 32 patients with age<70. Older age was not associated with adverse events (AE) (G3-5) or overall survival (OS). However, medical AE and 1-year mortality were more frequent in the group with age>70 (p=0.025). Significant prognostic factors associated with OS in all patients were PS=2/3 (p=0.002), CC-2/3 (p=0.022), and AE(G3-5) (p=0.005). However, analysis among the group with age>70 showed that AE was associated with OS, but PS or CC was not. On the other hand, among the group with age<70, PS and CC were associated with OS, but AE was not.

Conclusions: Impact on the prognostic factors were different between the groups of older age and younger age. AE was associated with poor prognosis, but PS or CC was not in older patients. These correlations were inverse in younger patients. The influence of older age should be considered, when the indication of CRS+HIPEC for PC of appendiceal origin is decided.