Title: Essential Role of Translational ADME and PK/PD in Drug Discovery and Development Investigations of translational ADME and PK/PD play an essential role in successful advancement of drug discovery into clinical development. To achieve the ultimate goal of delivering the right amount of drug to the right issue safely, generation of decision-making data is much more critical than simply producing a large volume of data. In this talk, examples and approaches will be discussed to demonstrate how translational ADME and PK/PD research with clear objectives can impact the programs from lead optimization to clinical trial. Problem-solving approaches are successfully applied to characterize and minimize critical issues including accurate prediction of drug-drug interaction and PK/PD relationship. The talk will also emphasize the importance of close collaboration of ADME scientists with colleagues of other fields during the course of drug discovery and development.