Institute Scientist Broad Institute of Harvard and MIT
Disclosure: Disclosure information not submitted.
Microscopy images contain tremendous information about the state of cells, tissues, and organisms. We aim to go beyond measuring individual phenotypes that biologists already know are relevant to a particular disease. Instead, in a strategy called image-based profiling, we stain many cellular components and extract thousands of morphological features from each cell’s image, often using an assay called Cell Painting. We then harvest similarities in these “profiles” to identify, at a single-cell level, how diseases, drugs, and genes affect cells, which can uncover small molecules’ mechanism of action, discover disease-associated phenotypes, identify the functional impact of disease-associated alleles, and identify novel therapeutics.