This tutorial will discuss how Sygnature Discovery’s new HTS system offers a fully automated platform to deliver high data fidelity with integrated compound tracking. Over the last few years we collaborated with leading industrial vendors to optimally integrate the best in compound management, HTS automation and data analysis. With this new, novel system we can now design and order assay plates in Titian Mosaic SampleBank software, run the fully automated screening process on the HighRes automated system, with data analysis and approval with Genedata Screener. The potential for manual operator errors and process bottlenecks is significantly reduced in this integrated workflow, leading to more robust and higher quality screening. Currently our HTS system is being used to screen Sygnature Discovery’s 150K custom Lead Finder compound library and continues to add to a growing track record of delivering quality novel chemical starting points suitable to start new projects.
In summary HTS has been established at Sygnature in Nottingham, UK, to complement our existing suite of hit finding approaches to offer a more comprehensive integrated hit discovery platform to enable more successful early drug discovery for our clients.