Automation and High-Throughput Technologies
Automating Chemistry in the age of AI
In late 2017 AstraZeneca undertook an internal “hack-a-thon”, bringing together a diverse skill set to investigate our ambition of fully automated chemical synthesis for drug-like compounds. Over the past 2 years we have evolved 4 prototypes to better understand the challenges associated with all stages of a multi-step synthesis process. In this presentation we will review our most recent evolution, realising fully automated batch and flow chemistries to fuel automated synthesis. We will describe in detail the integration and optimisation of the Zinsser SOPHAS platform for batch chemical synthesis; along with the varied Waters devices for product purification and analysis.
To achieve seamless integration, we have selected a third-party process scheduling software. Here we will cover the development of new drivers, protocols and interfaces for chemistry system control, along with the unusual demand of tracking and scheduling both single vial and associated plate-based activities (and the interplay between the 2 formats).
Looking forward to our 5th iteration, we’ll discuss our plan for pre-cursor storage, along with our concepts for how reactions could be constructed using the Zinsser REDI platform.