Advances in Bioanalytics and Biomarkers
Target Engagement and Pathways
The metabolome, the small molecule chemical entities involved in metabolism, has traditionally been studied with the aim of identifying biomarkers in the diagnosis and prediction of disease. However, the value of metabolomics has been redefined from a simple biomarker identification tool to a technology for the discovery of active drivers of biological processes. In this presentation, I will describe the molecular mechanisms by which the active cell metabolome affects cellular physiology through modulation of other ‘omic’ levels, including the genome, epi-genome, transcriptome and proteome. This concept of activity screening guided by metabolomics to identify biologically active metabolites, or “activity metabolomics”, is having broad impact on biology.