Demonstrating translational relevance of organoid and multicellular tissues for preclinical models of human disease
Bioprinting has recently emerged as an enabling technology in tissue biofabrication at high fidelity. This talk will discuss our recent efforts on developing a series of advanced bioprinting strategies, including sacrificial bioprinting that allows generation of perfusable microchannels embedded in hydrogel microchannels, microfluidic and hollow fiber bioprinting that achieves production of standalone cannular tissues, and multi-material bioprinting based on both extrusion and stereolithograpic modalities that enables creation of complex hierarchical tissue microstructures. Innovations in various cytocompatible and bioactive bioink formulations will also be presented. These platform bioprinting methods have been demonstrated to facilitate faithful fabrication of biomimetic tissues and their models spanning from the heart, liver, and musculoskeletal system to blood vessels and beyond, as well as their diseased forms, for applications in regenerative medicine and in accurate screening of therapeutic agents.