Micro- and Nanotechnologies
Microdevices for high-throughput cellular and biomolecular profiling
The capacity of cells to self-organize into tissues is critical to their normal developmental and their ability to self-repair. Thus, a better understanding of how tissues self-organize will improve our ability to synthesize tissues and organs in the lab, and suggest new strategies to slow the breakdown of tissue structure that contributes to the initiation and progression of disease. We are working to understand the mechanisms used by cells to self-organize robustly in the breast and gut, and how these program are susceptible to the perturbations that underlie diseases such as cancer. We are also developing new single cell analysis technologies to help decode the logic of paracrine signaling networks that support the self-organization of these tissues.