Assay Development and Screening
Optimization of Assays for Challenging Targets for Lead Discovery and Screening
Self-assembling protein microarrays can be used to study protein-protein interactions, protein-drug interactions, search for enzyme substrates, and as tools to search for disease biomarkers. In particular, recent experiments have focused on using these protein microarrays to search for antibody responses in patients with cancer, autoimmune and infectious diseases. This approach has led to the first CLIA-certified blood test for the early detection of breast cancer, Videssa™. Recent work has focused on using the arrays to explore post translational modification of proteins and its role in producing neoantigens in disease.