Small Molecule Libraries
Modern human genetics has underscored the important role that the immune system plays in many human diseases ranging from autoimmunity to neurodegeneration to cancer. Nonetheless, chemical probes are still lacking for many immunologically relevant proteins and protein classes. We have applied an integrated phenotypic screening and chemical proteomic strategy to globally map the druggable proteome of human immune cells. Leveraging extensive past knowledge on the special capacity of cysteine-reactive small-molecule electrophiles to perturb immune system function, we have profiled this class of compounds against thousands of cysteines in primary human immune cells and will present compelling evidence that this strategy has already identified hit compounds for diverse classes of proteins with genetic links to human immune disorders.