Assay Development and Screening
Development of Cellular Assays to Understand Protein Homeostasis
Targeted protein degradation has the potential to open the door to therapeutic targets previously deemed undruggable. In this talk, I will present the characterization of two ligase ligands and show how target degradation coupled with modulation of ligase biology leads to increased cellular efficacy. I will also share results on a new method for inducing the degradation of an ubiquitin ligase.