Small Molecule Libraries
High-throughput screening (HTS) libraries and DNA-encoded libraries (DELs) are two key repositories from which active hit compounds can be identified. FORMA has implemented a screening paradigm that enables HTS and DEL in parallel to enhance the likelihood of discovering hits for a particular target. Utilizing both methodologies in parallel allows us to thoroughly sample an expanded chemical space compared to either individually as well as evaluate potentially unexpected mechanisms of action (MOA) for each target. We will present our current success using the combined approach as well as a retrospective analysis of how expanded chemical space and novel MOAs could have further enhanced our past success delivering lead compounds.