Assay Development and Screening
Advanced Imaging & High-Content Assays
Cell-based imaging assays are used extensively for drug discovery; however, challenges remain in the translation of in vitro data to in vivo outcome. We are focused on generating relevant and translatable high content imaging data from physiologically relevant cell models, including 3D structures. Case studies will be presented on the application of high content imaging assays to several complex, physiologically relevant cell-based models, including ex-vivo patient-derived xenografts for assessment of tumor/immune cell interactions in the tumor microenvironment; iPSC derived mini-brains for assessment of neuronal health, and cell painting in 3D organoids.