Development of a T Cell stimulation assay for profiling agonistic antibodies, and application of FirePlex assays to high-throughput screening

Tuesday, January 28, 2020

12:30 PM – 1:15 PM

Room/Location: Room 1A

Exhibitor Tutorial Organizer(s)

GL

Greta Lindberg

Disclosure: Disclosure information not submitted.

Exhibitor Tutorial Presenter(s)

Paul Wylie, Ph.D

Director of Multiplex Applications
Abcam

Disclosure: Disclosure information not submitted.
Jessica Whitehouse

Senior Scientist
Cancer Research UK- Medlmmune Alliance Laboratory

Disclosure: Disclosure information not submitted.

The talk will provide an overview of the remit and capabilities of the Cancer Research UK AstraZeneca Antibody Alliance Lab. Focusing on an ongoing project within the immune-oncology area, I will describe our efforts to set up and optimize a T cell stimulation assay for characterization of a panel of antibodies. I will highlight the challenges including donor variability and a small assay window, and describe how the Fireplex platform has enabled us to explore cytokine release as an alternative assay readout.