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1/27/2020

2:00 PM – 3:00 PM 3D-Printed Devices For 96-well Gas Control (1000-A)

2:00 PM – 3:00 PM Artificial Intelligence and Computer Vision Strategies for Automated Gene Editing using a Nanofountain Probe Electroporation (NFP-E) System (1005-A)

2:00 PM – 3:00 PM Optimizing Nanodiamond-Doxorubicin Complexes toward Efficient Drug Loading and Sustained Release (1010-A)

2:00 PM – 3:00 PM Characterization of laser-etched grooves for use in paper-based analytical devices (1015-A)

2:00 PM – 3:00 PM High throughput label free optical analysis and sorting of cells and particles in microfluidic systems (1020-A)

2:00 PM – 3:00 PM Development of a gold nanoparticle-based colorimetric sensor for a sensitive endotoxin detection in aqueous solutions (1025-A)

2:00 PM – 3:00 PM A Low-Cost, No-Required-Skill, 3D-Printed Peristaltic Pump for Multi-Channel Systems in any Lab (1030-A)

2:00 PM – 3:00 PM High-content screening of millions of single-cell variants enabled by single-cell in situ tagging (1035-A)

2:00 PM – 3:00 PM Novel application of proteolysis targeting chimera technology for target identification of the liver receptor homolog-1 modulator SR1848 (1040-A)

2:00 PM – 3:00 PM Long-Term Synergistic Inhibition of Kinase Pathways Overcomes Drug Resistance of Colorectal Cancer Spheroids (1045-A)

2:00 PM – 3:00 PM Electrochemotherapy efficacy evaluation using Lab on a chip system (1050-A)

2:00 PM – 3:00 PM Organ-on-a-chip: three-dimensional pancreatic islet model under flow condition. (1055-A)

2:00 PM – 3:00 PM Environmentally friendly manufacturing of flexible graphite electrodes for wearable zinc monitoring in sweat. (1060-A)

2:00 PM – 3:00 PM Ultra-high-throughput screening platform for inhibitors targeting MKK3-MYC interaction for therapeutic discovery (1065-A)

2:00 PM – 3:00 PM A novel medium-throughput imaging assay to determine how glial cells respond to pathogens (1070-A)

2:00 PM – 3:00 PM A Simple and Rapid Method for Nucleic Acids Extraction and Purification from Complex Plant Samples (1075-A)

2:00 PM – 3:00 PM Combined VEGF and PDGF therapy to repair secondary injury induced by spinal cord injury (1080-A)

2:00 PM – 3:00 PM Application of Deep learning for Cell Printing Event Classification within Piezoelectric Inkjet Nozzles (1085-A)

2:00 PM – 3:00 PM Airway-On-A-Chip: Development and In Vitro Validation of A Microfluidic Cell Culture Model for Chronic Obstructive Pulmonary Disease (COPD) (1090-A)

2:00 PM – 3:00 PM Instrument-free fabrication of microfluidic paper-based analytical devices through 3D pen drawing for point-of-care testing (1095-A)

2:00 PM – 3:00 PM Rapid and Sensitive Detection of Citrus tristeza virus by using micro-homogenizer and reverse transcriptase-loop mediated isothermal amplification (RT-LAMP) (1100-A)

2:00 PM – 3:00 PM Automated Nano-fountain Probe Electroporation for Combinatorial Single Cell Transfection (1105-A)

2:00 PM – 3:00 PM Lab Automation in the Undergraduate Chemistry Curriculum (1110-A)

2:00 PM – 3:00 PM Metabolomics: A Strategy for Monitoring Partial Enteral Nutrition Treatment and Identifying Metabolic Signatures of Inflammation in Paediatric Crohn’s Disease Patients in Remission (1115-A)

2:00 PM – 3:00 PM In silico High-Throughput Screening by Machine Learning for the Discovery of New Treatments for Chagas Disease (1120-A)

2:00 PM – 3:00 PM Pooled Cell Painting for Massively Multiplexed Optical Phenotyping (1125-A)

2:00 PM – 3:00 PM Real-time tracking of droplets and single cells at 12,000 events per second using GPU-accelerated image processing (1130-A)

2:00 PM – 3:00 PM Smartphone-based colorimetric bacterial detection platform for antibiotic assisted screening (1135-A)

2:00 PM – 3:00 PM Delivering a Fully-Automated Cellular Absorption/Distribution/Metabolism/Excretion Assay Platform to Drive Speed to Results (1136-B)

2:00 PM – 3:00 PM High-throughput Organotypic Breast Tumor Model Elucidates Dynamic Remodeling of Tumor Microenvironment (1140-A)

2:00 PM – 3:00 PM chemBIOS – A Multidisciplinary Platform for Unifying Early-Stage Drug Discovery (1145-A)

2:00 PM – 3:00 PM Microfluidic Platform for Optimizing the Formation of Nanodisc Libraries from Whole Cell Lysate to Enable Activity-Based Profiling (1150-A)

2:00 PM – 3:00 PM Testing Funnel for Identification and Characterization of Small Molecule Modulators targeting Secretin Receptors (1155-A)

2:00 PM – 3:00 PM Lossless Immunocytochemistry for Precious Cell Samples (1160-A)

2:00 PM – 3:00 PM A Microfluidic-Free Method to Perform Ultra-Sensitive ELISA on Cytometer Compatible Microgels (1170-A)

2:00 PM – 3:00 PM BioLumin - An Immersive Mixed Reality Experience for Interactive Biomedical Visualization (1175-A)

2:00 PM – 3:00 PM High-throughput assessment of calcium signaling in MDA-MB-231 breast cancer cells expressing the genetically encoded calcium indicator GCaMP6m and cultured in different matrix stiffness (1180-A)

2:00 PM – 3:00 PM Nanomolar and parallel solid phase synthesis in droplet microarrays for UV-triggered on-chip cell screening (1185-A)

2:00 PM – 3:00 PM Microfluidic Platform for the Formation of Tissue-Engineered Blood Vessels from Aligned Collagen Sheets (1200-A)

2:00 PM – 3:00 PM Evaluating the advantages of using 3D-enriched fragments for targeting bromodomains. (1205-A)

2:00 PM – 3:00 PM Air-sealed Multi-Dimensional (MD) digital assay for detection of inhibitor-resistant influenza virus (1210-A)

2:00 PM – 3:00 PM Development of a Low-Cost Plate Reader for UV-Vis-NIR Spectroscopy in an Undergraduate Laboratory (1215-A)

2:00 PM – 3:00 PM Knowledge-based Approach for Illuminating the Dark Targets in the Human Genome (1220-A)

2:00 PM – 3:00 PM Near-Patient Drug Testing: A Concept to Facilitate Drug Discovery, Development and Personalized Treatments (1225-A)

2:00 PM – 3:00 PM Neuronal recordings using fluid walls (1230-A)

2:00 PM – 3:00 PM Rapid nanoscale high throughput design, synthesis, analysis, and screening using acoustic technologies (1235-A)

2:00 PM – 3:00 PM Towards label-free prediction of response to radiation therapy using Raman spectroscopy (1240-A)

2:00 PM – 3:00 PM An Electronic Nose to Differentiate Bacterial Species Based on Their Metabolic Volatile Organic Compounds (1245-A)

2:00 PM – 3:00 PM Barium salt nanoparticle loaded insulin oral formulations and their efficiency in controlling hyperglycemia in diabetic animals (1250-A)

2:00 PM – 3:00 PM Fabrication and Physical Characterization of Fe/Mg-Carbonate Apatite (Fe/Mg-CA): A Smart, Uniform and pH Responsive Carrier for Delivery of Doxorubicin (DOX) in Breast Cancer Cells with an Inimitable Protein Corona (1255-A)

2:00 PM – 3:00 PM Rapid and automated execution of high-dimensional space-filling Design of Experiments model using liquid-handling (1265-A)

2:00 PM – 3:00 PM The Future of Warfarin Dosing: Harnessing the Potential of CURATE.AI for Warfarin Dose Optimisation (1270-A)

5:00 PM – 6:00 PM Design and synthesis of selective HDAC6 inhibitors exerting potent antiproliferative effects on colon cancer cells (1001-B)

5:00 PM – 6:00 PM High-throughput analysis of synthetic samples from high-density microplates with ESI-MS enabled by the acoustic-droplet-ejection to the open-port probe sampling interface (1006-B)

5:00 PM – 6:00 PM A standardized and scalable angiogenesis assay using iPSC-derived endothelial cells. Enabling phenotypic screening in cardiovascular drug discovery (1011-B)

5:00 PM – 6:00 PM Automation of sample preparation for an efficient protein quantification workflow for proteomics. (1016-B)

5:00 PM – 6:00 PM Library preparation miniaturization: Effects of miniaturization on next generation sequencing data (1021-B)

5:00 PM – 6:00 PM Targeting RNA modifying enzymes for the treatment of cancer (1026-B)

5:00 PM – 6:00 PM A novel, robust, label free system for measuring post translational modification of proteins. (1031-B)

5:00 PM – 6:00 PM Development of a High-Throughput Virus Neutralization Assay for Multiple Influenza Strains (1036-B)

5:00 PM – 6:00 PM An enabling label-free and high-throughput platform for RNA drug discovery using self-assembled monolayer desorption ionization mass spectrometry. (1041-B)

5:00 PM – 6:00 PM From Tube to Plate: XAVO® Lab Logistics Wizard Guides Workflow for Acoustic Assay-Ready-Plate Production (1046-B)

5:00 PM – 6:00 PM New Centralized Software for Automation System Control and Device/Workflow Scheduling (1051-B)

5:00 PM – 6:00 PM Use of High Content Imaging to Compare 2D and 3D Cell Culture Approaches to Model Steatosis, Inflammation, and Fibrosis in the Context of NASH (1056-B)

5:00 PM – 6:00 PM New laboratory automation system for physiologically relevant cell-based assays. (1061-B)

5:00 PM – 6:00 PM A Web-Based Tool for Real-Time Monitoring of High-Throughput Screening Results (1066-B)

5:00 PM – 6:00 PM Automated Long-term 3D Cell-Based Toxicity Studies Using a Novel Flowchip System (1071-B)

5:00 PM – 6:00 PM Building Powerful Applications on an Organized Data Infrastructure to Enable Automation and Large Scale Data Capture (1076-B)

5:00 PM – 6:00 PM Corning Matrigel Matrix-3D plates for High-throughput 3D Assays (1081-B)

5:00 PM – 6:00 PM Development of a human neuronal cell model of Beta-Propeller Protein-Associated Neurodegeneration (BPAN) as a drug screening platform (1086-B)

5:00 PM – 6:00 PM Discovery and screening of protein biomarkers with the FirePlex Technology Platform (1091-B)

5:00 PM – 6:00 PM Identification and Characterization of Non-Covalent Small Molecule Binders of mRNA and Proteins using Affinity Selection-Mass Spectrometry (1096-B)

5:00 PM – 6:00 PM Lab of the future – Are tomorrows dreams already today’s reality? (1101-B)

5:00 PM – 6:00 PM Polyethylene Glycol Biopolymer Based Thermo-responsive Nanocarriers For Enhanced Cellular Uptake, Controlled Release, and Imaging (1106-B)

5:00 PM – 6:00 PM Using custom hardware, open-source, and cloud computing for rapid, vendor-agnostic assay onboarding and enzyme screening (1111-B)

5:00 PM – 6:00 PM Use virtual screening to augment the diversity screening library in high-throughput screening (1116-B)

5:00 PM – 6:00 PM Preservation of fresh human peripheral blood mononuclear cells using BeadReady™ (1121-B)

5:00 PM – 6:00 PM Flexible fluid-walled conduits for accurate cell-based assays (1126-B)

5:00 PM – 6:00 PM Assessment of compound efficacy and safety for glioblastoma treatment in a multiplexed human High Throughput Screening platform. (1131-B)

5:00 PM – 6:00 PM Glycerol-3-Phosphate Acyltransferase 1 (GPAT1) for the Treatment of NAFLD/NASH: Optimization of a HTS capable fluorogenic CoA detection assay to identify inhibitors of GPAT1 (1141-B)

5:00 PM – 6:00 PM High-throughput Screening for the Identification of SOD1 Modulators in Amyotrophic Lateral Sclerosis (1146-B)

5:00 PM – 6:00 PM High-throughput dissolution and permeation of solid-state drugs (1151-B)

5:00 PM – 6:00 PM Robotic Cell Culture, Multi-Lineage Directed Differentiation, and Translational Application of Human iPSCs (1156-B)

5:00 PM – 6:00 PM The OrganoTEER: A sensitive TEER measurement platform for high-throughput screening of Organs-on-Chips (1161-B)

5:00 PM – 6:00 PM Kinetic Characterization of Extremely Potent EZH2 Inhibitors by TR-FRET (1166-B)

5:00 PM – 6:00 PM Acoustic Droplet Ejection of Human Genomic DNA (1171-B)

5:00 PM – 6:00 PM The Use of High Content Imaging and Viability Readouts for Screening with 3-D Spheroids (1176-B)

5:00 PM – 6:00 PM A Homogeneous FRET-based HTS Assay for quantification of pRb in Breast Cancer Cell Lines to monitor inhibition of GO / G1 cell phase transition (1181-B)

5:00 PM – 6:00 PM Multi-Mode Metabolic Profiling of Stationary Phase Saccharomyces cerevisiae Exposed to Short-term Oxidative or Nutrient Stress (1186-B)

5:00 PM – 6:00 PM The LabDroid Project: a Novel Automation Platform for High-Throughput Protein and Peptide Characterization (1191-B)

5:00 PM – 6:00 PM Automation of organ-on-chip technologies: the role of standards (1196-B)

5:00 PM – 6:00 PM Standardization of whole blood immunophenotyping using an automated staining protocol and recombinant antibodies (1201-B)

5:00 PM – 6:00 PM Acoustic Re-array Dilution, A New Workflow for the Creation of Dose Response Compound Plates (1206-B)

5:00 PM – 6:00 PM Automated Three-Dimensional Cell-Based Assays in Nanofibrillar Cellulose Hydrogels (1211-B)

5:00 PM – 6:00 PM A Novel Objective Waveform Analysis for Providing Bias-free Multiparametric Outputs for Classifying Biological Mechanisms and High-Throughput Screening Results (1216-B)

5:00 PM – 6:00 PM ONCO-Chip3D technology: a microfluidic platform for physiologically relevant drug screening and precision medicine (1221-B)

5:00 PM – 6:00 PM Water immersion objectives for automated high-content imaging to improve precision and quality of complex biological assays (1226-B)

5:00 PM – 6:00 PM Small Molecule Phenotypic Screen Involving Physiologically Relevant Model System, Primary Human Macrophages, Reveals Novel Disease-Relevant Targets for Autoimmune Drug Discovery (1231-B)

5:00 PM – 6:00 PM A microplate reader approach for faster detection of endotoxin using a fluorescence based assay (1236-B)

5:00 PM – 6:00 PM Application of mass spectrometry for HTS and SAR at AbbVie Inc. (1241-B)

5:00 PM – 6:00 PM Deep learning for organic reaction discovery (1246-B)

5:00 PM – 6:00 PM Equivalence Study of the Preparation of NGS Libraries with a Janus G3 Liquid Handler in a Clinical Laboratory (1251-B)

5:00 PM – 6:00 PM Highly Sensitive ELISA's in 90-minutes (1256-B)

5:00 PM – 6:00 PM Kinase selectivity profiling in live cells using the NanoBRET target engagement assay (1261-B)

5:00 PM – 6:00 PM On-chip analysis, indexing, and screening for high-productive bacteria in a microfluidic static droplet array (1266-B)

5:00 PM – 6:00 PM A Highly Automated End-to-End Analysis Workflow for High-Throughput Mass Spectrometry Screening (1271-B)

5:00 PM – 6:00 PM Automated microtissue handling enables large-scale assembly of microfluidic multi-tissue experiments (1276-B)

5:00 PM – 6:00 PM Dynabeads for flexible and robust sample processing on Hamilton NIMBUS Presto. (1281-B)

5:00 PM – 6:00 PM Controlling Automation Trainer’s Good Liquid Handling (GLH) modified tartrazine-based single-dye method in qualification of automated liquid handlers and pipettes for use in industry applications (1286-B)

5:00 PM – 6:00 PM Rapid Machine Learning Route Design and Automated Synthesis of Drug-like Molecules Demonstrated by the Continuous Multistep Synthesis of three Nucleoside Antivirals in One Day (1291-B)

5:00 PM – 6:00 PM Bringing new insights on RTK signaling: Development of an innovative and adaptable BRET biosensor platform (1296-B)

5:00 PM – 6:00 PM An interoperable, flexible qPCR automation workflow for a range of liquid handlers (1301-B)

5:00 PM – 6:00 PM Utilizing In-House Automation, Informatics Solutions, and Triage Assays to Detect False Positives and Streamline the High-Throughput Screening Process (1306-B)

5:00 PM – 6:00 PM Challenges and Solutions in the Development of an Assay Suitable for Measurement of Glycan-Directed Enzymatic Activity (1311-B)

5:00 PM – 6:00 PM A Microscopy based High Throughput Screen to Identify Novel Therapeutics for Breast Cancer in 3D spheroids (1316-B)

5:00 PM – 6:00 PM Rapid Assessment of Drug Effects on Cellular Proliferation and Multiple Biomarkers using AlphaLISA and the EnSight Multimode Plate Reader in a Colorectal Cancer Model (1321-B)

5:00 PM – 6:00 PM Automated CRISPR Engineering platform enables high throughput cell line production and validation of antibody reproducibility at scale (1326-B)

5:00 PM – 6:00 PM The Robustness Scoring Method In Label-free Spheroid Morphological Analysis For Their Quality Evaluation (1331-B)

5:00 PM – 6:00 PM Pooled image-based phenotypic screening in human cells enabled by ghost cytometry with DNA barcoding technology (1336-B)

5:00 PM – 6:00 PM Getting ready for screening? Evaluation of acCELLerate Assay Ready Cells for Alpha Surefire® CETSA® HT screening (1341-B)

5:00 PM – 6:00 PM In-Vitro pharmacology plan for the identification of Branched-Chain Keto- Acid Dehydrogenase Kinase (BDK) inhibitors (1346-B)

5:00 PM – 6:00 PM Adenovirus-mediated CRISPR/Cas9 gene editing in patient primary fibroblasts to validate potential drug targets in lung fibrosis (1351-B)

5:00 PM – 6:00 PM Enabling Discovery of cGAS Antagonists with the Transcreener® cGAS Assay (1356-B)

5:00 PM – 6:00 PM Developing a novel assay platform to measure functional activity of GCase using a lysosomotropic substrate (1361-B)

5:00 PM – 6:00 PM Real-time Monitoring of PROTAC and Molecular Glue Targeted Degradation in Living Cells (1366-B)

5:00 PM – 6:00 PM A Freeze-Thaw Performance Comparison Between FluidX AcoustiX Sample Tubes vs. REMP 96 Storage Tubes (1371-B)

1/28/2020

1:00 AM – 2:00 AM Modeling the tumor microenvironment in HTS for drug discovery and precision medicine (1117-C)

2:00 PM – 3:00 PM Panning for Metals (1002-C)

2:00 PM – 3:00 PM The PreON platform - a fully automated end-to-end solution for the Biologist enabling efficient sample preparation for mass-spectrometry-based workflows. Created by Automation engineers & a start up in a complementary alliance. (1007-C)

2:00 PM – 3:00 PM Low-Cost Digital Dispensing for Quantitative PCR (1012-C)

2:00 PM – 3:00 PM A Novel Deep Learning and Machine Vision System for Automating Blood Fractionation on a High-Throughput Liquid Handling Platform (1017-C)

2:00 PM – 3:00 PM Rapid lateral flow assay development using an automated liquid handling robot (1022-C)

2:00 PM – 3:00 PM The Future of Laboratory Automation: Elevating the Science via a Novel Pipetting Algorithm, 3D-Printing Technology and a Next-Generation Advanced Control Machine (1027-C)

2:00 PM – 3:00 PM Development of screening platforms to target the "undruggable" focal adhesion targeting (FAT) domain (1032-C)

2:00 PM – 3:00 PM Combinatorial phenotypic screening with active learning and automated experiments (1037-C)

2:00 PM – 3:00 PM An Innovative Method for the Efficient, High-Throughput Transfection of Primary Human T-Cells (1042-C)

2:00 PM – 3:00 PM Hematopoietic stem cell niche generation through droplet microfluidics (1047-C)

2:00 PM – 3:00 PM Synergy and Mechanism of Action: The BRAID Model of Drug Interaction (1052-C)

2:00 PM – 3:00 PM Verification of decontamination procedure “ContraCon™ decontamination routine” with the Cytomat™ 10 (1057-C)

2:00 PM – 3:00 PM A Novel Automated Platform for Peptide Mapping Analysis of Biopharmaceutical Products (1062-C)

2:00 PM – 3:00 PM Accelerating the Discovery of Therapeutic Antibodies Using High Throughput SPR (1067-C)

2:00 PM – 3:00 PM Automating Pattern Recognition in High Content Screening and Biomarker-dependent Patient Stratification with Advanced Flow Cytometry and Machine Learning (1072-C)

2:00 PM – 3:00 PM Complex event analysis for neurotoxic profiling of compound effects on human iPSC-derived neural spheroid 3D cultures (1077-C)

2:00 PM – 3:00 PM Detecting allele-specific genome editing outcomes using a fluorescence-based screening method (1082-C)

2:00 PM – 3:00 PM Development of custom single-cell assay protocols using the open architecture of the ICELL8 cx system (1087-C)

2:00 PM – 3:00 PM Double Dipping: Making the Most from an Echo Source Plate (1092-C)

2:00 PM – 3:00 PM Imaging-based mapping of context-specific drug effects (1097-C)

2:00 PM – 3:00 PM New state-of-the-art fully automated analytical approach at Lilly Life Sciences Studio (L2S2): from crude reaction to pure compound (1102-C)

2:00 PM – 3:00 PM Programmatic Cloud Lab for Drug Discovery (1107-C)

2:00 PM – 3:00 PM Volumetric Quality Control for Sample Management Automated Applications Using Low-Coherence Interferometry (1112-C)

2:00 PM – 3:00 PM Improving fragment-based drug discovery with Dianthus for biophysical high-throughput screening (1122-C)

2:00 PM – 3:00 PM Towards an Open Standard Interface for Chromatography Data Systems (1127-C)

2:00 PM – 3:00 PM Rapid Assembly of Synthetic DNA Libraries for Protein Engineering and Generating Antibody Diversity (1132-C)

2:00 PM – 3:00 PM High Throughput profiling of cardio-active compound response between 2D monolayers, anisotropic and 3-dimensional human induced pluripotent stem cell-derived cardiomyocytes. (1137-C)

2:00 PM – 3:00 PM Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A Tumour Model to Functionally Assess Stromal Impact on Tumour Regrowth (1142-C)

2:00 PM – 3:00 PM Automated Hign-Throughput N-Glycan Preparation Workflow on a Commercially Available Benchtop Pipetting Robot (1147-C)

2:00 PM – 3:00 PM Understanding Sources of Assay Variability: The Key to Successful Automation Optimization (1152-C)

2:00 PM – 3:00 PM Centrifuge-less, automation-ready red blood cell lysis and immunostaining of whole blood for flow cytometry using Laminar Wash washer and plate (1157-C)

2:00 PM – 3:00 PM Analysis of RNA transcript levels reveals upregulation of hypoxia markers for pancreatic cancer cells cultured in 3D (1162-C)

2:00 PM – 3:00 PM Evaluation of incubator by edge effect of microwell plate. (1167-C)

2:00 PM – 3:00 PM Development of Open Source Microplate Illumination Panels (1172-C)

2:00 PM – 3:00 PM Acoustic Droplet Ejection from Phase-Separated Liquid Extractions for High-Throughput Mass Spectrometry (1177-C)

2:00 PM – 3:00 PM Innovative Solid Phase Extraction Tips for micro extraction of multi-class pharmaceutical compounds in human plasma prior to analysis by LC-MS/MS (1182-C)

2:00 PM – 3:00 PM Validation of Chemical Matter Through In-House Orthogonal Assay Platforms (1187-C)

2:00 PM – 3:00 PM Top Tips and Considerations to Successfully Image 3D Cell Model Systems using a High Content Screening platform (1192-C)

2:00 PM – 3:00 PM A New Method to Generate Human Microglia from iPSC Derived Primitive or Definitive Hematopoietic Progenitors (1197-C)

2:00 PM – 3:00 PM Molecular and functional characterization of stem cells-derived glutamatergic neurons (eNeuron/glut) in support of drug discovery applications (1202-C)

2:00 PM – 3:00 PM A Live Cell High Content Assay for Cellular Lipid Droplets (1207-C)

2:00 PM – 3:00 PM LabTwin, the world´s first AI and voice-powered digital lab assistant (1212-C)

2:00 PM – 3:00 PM Vortex-actuated cell sorting for high-throughput phenotypic screening (1217-C)

2:00 PM – 3:00 PM Storage and shipment of human iPSC-derived cortical neurons at room temperature using WellReady™ (1222-C)

2:00 PM – 3:00 PM Sample management and customizable DB system (Dotmatics) (1227-C)

2:00 PM – 3:00 PM Single-cell protein electrophoresis: Polyacrylamide gel concentration affects electromigration and in-gel immunoprobing in an open microfluidic device (1232-C)

2:00 PM – 3:00 PM A pH determination method suitable for high-throughput approaches based on spectral absorbance (1237-C)

2:00 PM – 3:00 PM Comparison Agilent Fragment Analyzer and PerkinElmer LabChip GX Touch for use with gDNA Assessment (1242-C)

2:00 PM – 3:00 PM Development of a High-Throughput 1536W Multiplexed CellTiter-Glo and QuantiLuc Reporter Assay (1247-C)

2:00 PM – 3:00 PM Evaluation of Seven gDNA Extraction Methods for use with Frozen Cell Pellets in a Clinical Laboratory (1252-C)

2:00 PM – 3:00 PM High-throughput Assessment of Drug-Induced Cardiotoxic Effects in Human iPSC-Derived Cardiomyocytes (1257-C)

2:00 PM – 3:00 PM Mate Pair Automation Improves Library Consistency And Performance (1262-C)

2:00 PM – 3:00 PM Ultra High-Throughput Screening (UHTS) Strategies to Identify Small Molecule Scaffolds Enabling the Discovery of Novel Proteolysis Targeting Chimeras (PROTACs) (1267-C)

2:00 PM – 3:00 PM Detection of Insulin Action and Steatosis Using New Bioluminescent Metabolite Assays (1272-C)

2:00 PM – 3:00 PM A High Throughput Screen for HPK1 Inhibitors Using a New Automation Platform and the Sygnature LeadFinder Compound Library (1277-C)

2:00 PM – 3:00 PM Transcreener® CD73 Assay: A High Throughput, Sensitive Assay to Measure Adenosine (1282-C)

2:00 PM – 3:00 PM Development of an Automated Patch Clamp Assay for recording STIM1/Orai1 – mediated currents using Qube384 (1287-C)

2:00 PM – 3:00 PM A new engineered cellular model of cardiac fibrosis for High Throughput Screening (1292-C)

2:00 PM – 3:00 PM Concentration Measurement of Compounds Stocks in a High-Throughput profile by Chemiluminescent Nitrogen Detector (1297-C)

2:00 PM – 3:00 PM First-in-class meets best-in-class: Rapid antibody discovery on hard targets combined with fine-grained engineering and optimization (1302-C)

2:00 PM – 3:00 PM Flow Injection Mode modifies a RapidFire 365 system to enable high throughput screening and the mechanistic evaluation of many Histone Acetyltransferase and Protein Kinase enzymes (1307-C)

2:00 PM – 3:00 PM High content imaging system for discovering neuroprotective and neurotoxic compounds in an human induced pluripotent stem cell-derived neuron and microglia Alzheimer’s Disease model (1312-C)

2:00 PM – 3:00 PM Automated Dynamic In Vitro Assays used for Dose Projection Modeling using Suspension Cells (1317-C)

2:00 PM – 3:00 PM A High Throughput NGS Pipeline (1322-C)

2:00 PM – 3:00 PM Spinach splice sensor: a cell-based drug discovery platform for splicing-related diseases (1327-C)

2:00 PM – 3:00 PM PROTAC Drug Discovery: Lessons from a CRO (1332-C)

2:00 PM – 3:00 PM Lumit™ Immunoassays: Bioluminescent, Sensitive, and Homogeneous Analyte Detection Using Labeled Antibodies (1342-C)

2:00 PM – 3:00 PM NOMAD® Genetically encoded biosensors for multiplexing PAR2 Proteinase-activated receptor functional assay. (1347-C)

2:00 PM – 3:00 PM NanoBRET™ in Live Cells as a Method to Assess E3 Ligase and Target Protein Occupancy for PROTACs (1352-C)

2:00 PM – 3:00 PM Utilizing Additive Manufacturing in a Laboratory Setting to Save Time and Resources (1357-C)

2:00 PM – 3:00 PM In‐house well plate heating system development for SplitLuc CETSA assay, and improving heating andcooling efficacy of a Thermo‐Fisher thermal mixer adapted for flat‐bottom well plates (1362-C)

2:00 PM – 3:00 PM Beyond High Content Screening: An Open Next Generation Image Analysis Platform (1367-C)

2:00 PM – 3:00 PM A Development and Processing Methodology for St. Jude Library Introduction and Replenishment (1372-C)

5:00 PM – 2:00 AM Creation of a large-spectrum GPCR biosensor for functional in vitro safety and systems pharmacology analysis (1303-D)

5:00 PM – 6:00 PM Human Treg cells phenotypic assay development and screening using an automated multiplex flow cytometry assay (1003-D)

5:00 PM – 6:00 PM A Phenotypic Screen for Compounds that block cAMP-mediated Immunosuppression in the Tumor Microenvironment. (1008-D)

5:00 PM – 6:00 PM Identification of small molecules that increase productive cellular processing of antisense oligonucleotides (ASOs) (1013-D)

5:00 PM – 6:00 PM Live Cell Assays Reveal New Patterns of Cell Signaling in Neurodegenerative Disease Mutants (1018-D)

5:00 PM – 6:00 PM Re-engineering Bead-based Sandwich Immunoassays for High-Content and High-Throughput Screening (1023-D)

5:00 PM – 6:00 PM Rapid Multi-Population Cell Purification with Digital Magnetic Sorting (1028-D)

5:00 PM – 6:00 PM Developing Efficient Workflows in Support of Early Drug Discovery by Effectively Using Informatics, Instrumentation and Robotics (1033-D)

5:00 PM – 6:00 PM An Automated High-Throughput Robotic Sample Preparation Method For Measuring Urinary Nicotine Metabolites (1038-D)

5:00 PM – 6:00 PM CellacaTM MX: A novel instrument for high-throughput, high-speed cell counting, concentration, and viability (1043-D)

5:00 PM – 6:00 PM Thermal shift indicates that oxalic acid may be a prevalent contaminant of hits identified by high throughput screening (1053-D)

5:00 PM – 6:00 PM G6b-B: a new receptor for platelet production and function (1058-D)

5:00 PM – 6:00 PM A set of miniaturized high-throughput library protocols for RNA sequencing (1063-D)

5:00 PM – 6:00 PM An Automated High-Throughput Fluorescence in situ Hybridization (FISH) Assay Platform for Gene Expression Quantitation (1068-D)

5:00 PM – 6:00 PM Automation of Immunomagnetic Cell Isolation From Whole Blood, PBMCs, or Tumors (1073-D)

5:00 PM – 6:00 PM comPOUND meets acoustiX tube –how proven technology adapts to new tunes! (1078-D)

5:00 PM – 6:00 PM Developing an ultra high-throughput immunoassay platform for multiplex protein quantitation in early stage drug screening, using FirePlex® technology (1083-D)

5:00 PM – 6:00 PM Development of novel iPS-derived hepatocytes and intestinal epithelial cells to advance disease modeling and drug discovery (1088-D)

5:00 PM – 6:00 PM Dragonfly® discovery to enable and accelerate early stage drug discovery processes. (1093-D)

5:00 PM – 6:00 PM Impacts of Positive Displacement Dispensing on High Throughput Assay Performance (1098-D)

5:00 PM – 6:00 PM Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate (1103-D)

5:00 PM – 6:00 PM Real-time and label-free refractive index dispersion map of single axon in striatal medium spiny neurons by common-path triple-wavelength diffraction phase interferometry (1108-D)

5:00 PM – 6:00 PM High Throughput Screening (HTS) and Affinity Selection-Mass Spectrometry (AS-MS) for Early Drug Discovery (1113-D)

5:00 PM – 6:00 PM Reliable microneedle coating with a non-contact and drop-on-demand nano dispensing technology (1118-D)

5:00 PM – 6:00 PM Directly Linking Single T Cell Phenotype and Function to Genotype on the Lightning Platform (1123-D)

5:00 PM – 6:00 PM A human pancreatic spheroid platform for high throughput screening in toxicology and diabetes . (1128-D)

5:00 PM – 6:00 PM Using Improved Camera Technology to Increase Digital Microscopy Throughput (1133-D)

5:00 PM – 6:00 PM Isolation of functional cells straight from buffy coat, LRSC, and Leukopak (1138-D)

5:00 PM – 6:00 PM A High-Throughput Antibody Production Process for Generating Tens of Thousands of mAbs and Bispecifics at the milligram scale (1143-D)

5:00 PM – 6:00 PM Live Cell Transportation of Immobilized Midbrain Organoids in a shipping incubator (1148-D)

5:00 PM – 6:00 PM A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides. (1153-D)

5:00 PM – 6:00 PM Multi-Scale Imaging for cellular and organoid target studies (1158-D)

5:00 PM – 6:00 PM Rethinking Rare: Niemann-Pick Disease Type C2 Disease Model and Therapeutics Development (1163-D)

5:00 PM – 6:00 PM Automation Applied to Genetic Analysis of Embryonic Stem Cells Workflow (1168-D)

5:00 PM – 6:00 PM Real-Time Live-Cell Analysis of 3D Tumour Spheroid Invasion (1173-D)

5:00 PM – 6:00 PM Label-Free Drug Discovery: High-Throughput Screening of Enzyme Modulators with Mass Spectrometry (1178-D)

5:00 PM – 6:00 PM Examination of Intracellular Target Engagement for Clinically Relevant Inhibitors Across the CDK Family Using NanoBRET™ Assays (1183-D)

5:00 PM – 6:00 PM Spatial information on receptor clustering in flow cytometry using FRET (1188-D)

5:00 PM – 6:00 PM MULTIVAC: A Software Suite for the Management and Utilization of Laboratory Techniques for Molecular Cloning (1193-D)

5:00 PM – 6:00 PM Searching for Druggable AD Targets by Increasing Trem2 Surface Expression (1198-D)

5:00 PM – 6:00 PM Characterization of bi-specific T-cell engager (BiTE) antibody-mediated immune cell killing using a combined live-cell analysis and flow cytometry workflow (1203-D)

5:00 PM – 6:00 PM Tracking, Parsing, and Visualization of Automated High Throughput Screening Data Using the Palantir Foundry Platform (1208-D)

5:00 PM – 6:00 PM Bridging the gap between Mass Spectrometry and High-Throughput Screening with multiple file format analysis pipeline for Luxon Ion Source sub-second analysis (1213-D)

5:00 PM – 6:00 PM High-throughput RT-qPCR for small molecule screening assays in advanced cellular models (1218-D)

5:00 PM – 6:00 PM Automated multifactorial optimisation for a robust and device-agnostic 7-part construct assembly (1223-D)

5:00 PM – 6:00 PM Cell painting for compounds clustering and Mechanism of Action characterization (1228-D)

5:00 PM – 6:00 PM Screening Compound Libraries for HTS and Lead Discovery Projects (1233-D)

5:00 PM – 6:00 PM A whole-animal confocal imaging platform shows oscillating motor neuron activities in the basal motor neuron circuit (1238-D)

5:00 PM – 6:00 PM Analyzing binding kinetics with time-resolved fluorescence resonance energy transfer (1243-D)

5:00 PM – 6:00 PM Development of Novel Biochemical Assays for the Screening of monoPARP Enzymes (1248-D)

5:00 PM – 6:00 PM Exosome marker detection: an exquisitely sensitive Europium Time Resolved Immunofluorescence assay (1253-D)

5:00 PM – 6:00 PM Introducing FLIPR Tetra as a Novel Application for Capturing High-Throughput Biochemical Kinetic Data (1258-D)

5:00 PM – 6:00 PM Nanoparticle Covered Carbon Nanotubes as Neural Substrates (1263-D)

5:00 PM – 6:00 PM Ultra-Fast Mass Spectrometry (MS)-Based Analysis of Metformin for Determining Renal Transporter Inhibition Using Acoustic Droplet Ejection (ADE) with an Open Port Probe (OPP) Interface (1268-D)

5:00 PM – 6:00 PM Completing End-to-End Assay Automation with Automated Data Analysis (1273-D)

5:00 PM – 6:00 PM Implementing Automated Sample Preparation Strategies for the Quantification of Drugs of Abuse and Pain Management Drugs (1278-D)

5:00 PM – 6:00 PM CSox-based Sensors for Continuous, Homogeneous and Quantitative Monitoring of Protein Kinase and Phosphatase Activity (1283-D)

5:00 PM – 6:00 PM A simple, gravity-flow Protein A column with high recovery and minimal dilution in a format suitable for automated high-throughput screening. (1288-D)

5:00 PM – 6:00 PM Droplet-based microfluidic optical calorimeter (1293-D)

5:00 PM – 6:00 PM Development and Manufacturing of Rapid Diagnostic Tests for Human and Animal Diseases (1298-D)

5:00 PM – 6:00 PM Targeting ENPP1 for Cancer Immunotherapy: Development of an HTS Method Using the Transcreener® AMP/GMP Assay (1308-D)

5:00 PM – 6:00 PM Washing and Re-use of Microplates Used for Infectious Organism-based Quantitative High Throughput Screening Assays (1313-D)

5:00 PM – 6:00 PM Novel Bioluminescent Tools to Study GPCR Pharmacology in Living Cells (1318-D)

5:00 PM – 6:00 PM Simultaneous Measurement of Chemokine/Cytokine Release and Antibody-Dependent Cellular Cytotoxicity upon Binding with Rituximab (1323-D)

5:00 PM – 6:00 PM Scripting Modular Assay Automation for Recipe Driven Development (1328-D)

5:00 PM – 6:00 PM Enabling High-Throughput Protein Expression and Optimization Through the Use of Robotics (1333-D)

5:00 PM – 6:00 PM Development and validation of NMDA receptor ligand-gated ion channel assays using the Qube 384 automated electrophysiology platform (1338-D)

5:00 PM – 6:00 PM A highly Scalable Analysis Solution for Transcriptomic Screening (1343-D)

5:00 PM – 6:00 PM Fluorescent Parkin cell-based assay development for the screening of drugs against Parkinson´s disease (1348-D)

5:00 PM – 6:00 PM Protein target class as a determinant of compound purity in screening hits: Determining quality control processes and suitable assay conditions for a particular target class and how to guide decisions on library composition (1353-D)

5:00 PM – 6:00 PM Physiological Function Assays for Muscular Dystrophy Therapeutics Screening with Stem Cell-derived Skeletal Myotubes (1358-D)

5:00 PM – 6:00 PM Effects of Hi-intensity versus Low-intensity UV LED Source Irradiance on Dose for RNase A Inactivation (1363-D)

5:00 PM – 6:00 PM Utilizing Mosaic sample management software and automation to facilitate high-throughput extracellular protein-protein interaction screening (1368-D)

5:00 PM – 6:00 PM Automation of Buffer Exchange for Multi-Attribute Method Monitoring of Purified Proteins (1373-D)

1/29/2020

11:30 AM – 12:30 PM Creating Niche Automation Solutions to Help Drive Innovation at Amgen (1004-E)

11:30 AM – 12:30 PM Breaking the Tyranny of Z’: Analyzing the significance of a ubiquitous assay performance metric. (1009-E)

11:30 AM – 12:30 PM The fast and victorious: level up your drug discovery with innovative mass spectrometry approaches (1014-E)

11:30 AM – 12:30 PM Centrifuge-less walk-away automation of cell immunostaining assays for superior flow cytometry data and reliable data tracking (1019-E)

11:30 AM – 12:30 PM High-throughput functional cell contractility assay suite for drug discovery and development (1024-E)

11:30 AM – 12:30 PM Quantitation of Interleukin-10 using a Novel Enzyme-linked Darkening Assay (ELDA) (1029-E)

11:30 AM – 12:30 PM Automating Assays- Lean workflows designed to support Pharmacology Efforts (1034-E)

11:30 AM – 12:30 PM Target Class Profiling of Small Molecule Methyltransferases: A Pilot Study (1039-E)

11:30 AM – 12:30 PM Characterization of Immune Cell Synapses for Use in Immuno-Oncology Screening Programs (1044-E)

11:30 AM – 12:30 PM Investigation of cell proliferation of HEK239 and HepG2 cells in the Cytomat™10 (1049-E)

11:30 AM – 12:30 PM Transforming Automation in Compound Management (1054-E)

11:30 AM – 12:30 PM A Flexible Automation Software Control Platform streamlining Instrument Integration enabling Novel Process Implementation (1059-E)

11:30 AM – 12:30 PM A versatile bioluminescent immunoassay approach to probe cellular signaling pathway regulation (1064-E)

11:30 AM – 12:30 PM Applying automation to a novel type 1 diabetes assay using Antibody Detection by Agglutination-PCR (1069-E)

11:30 AM – 12:30 PM Balancing library input and selection pressure in DNA encoded library screens (1074-E)

11:30 AM – 12:30 PM Corning Elplasia Plates for Assays with Multiple Spheroids Per Well (1079-E)

11:30 AM – 12:30 PM Development of a high throughput droplet-based miniaturized cell screening assay to validate on-bead encoded library platform, BELT (1084-E)

11:30 AM – 12:30 PM Development of Robust Screening Assays for Identifying Kinase Inhibitors (1089-E)

11:30 AM – 12:30 PM High Throughput siRNA Screen for Novel Fibrotic Target Identification (1094-E)

11:30 AM – 12:30 PM Intelligent Biophysical Screening and Characterization of fragments and biologics – shred any interaction with the Bruker Sierra SPR-32 (1099-E)

11:30 AM – 12:30 PM Nucleic Acid Binding Nanosep® Centrifugal Devices and AcroPrep™ Advance 96-well filter plates offer complementary options for low and high throughput nucleic acid purification (1104-E)

11:30 AM – 12:30 PM Three-Dimensional High-Throughput Cell Analysis Platform for Drug Evaluation in Patient-Derived Organoids and Spheroids (1109-E)

11:30 AM – 12:30 PM Magnetic Electrospun Micro-fibre Scaffold Assemblies: Examples of there use for 3-Dimensional Cell-Based Screening Applications (1114-E)

11:30 AM – 12:30 PM A framework for optimizing high content imaging of 3D models for drug discovery (1119-E)

11:30 AM – 12:30 PM Stimulation of Human Peripheral Blood Mononuclear Cells (1124-E)

11:30 AM – 12:30 PM Haploinsufficiency of RAI1 in Smith-Magenis Syndrome-derived Neural Progenitor Cells is Associated with Upregulated Genes Involved in Immune Response and Obesity (1129-E)

11:30 AM – 12:30 PM Anisotropic High Throughput human iPSC-derived Cardiomyocyte Cultures Display Differential Response to Chronic Oncology Compound-Related Toxicity. (1134-E)

11:30 AM – 12:30 PM High Throughput Automated Preparation of Amino Acids Using Waters Technologies AccQ-Tag Ultra Automation Kit and Cell Culture Standards. (1139-E)

11:30 AM – 12:30 PM Using Surface Plasmon Resonance to Determine Kinetics of Small Molecules Binding to Epigenetic Targets (1144-E)

11:30 AM – 12:30 PM Anti-Bacteria screening against S.aureus and P.aeruginosa using natural products of NNIBR library (1149-E)

11:30 AM – 12:30 PM High volume, label-free capture and enrichment of cells (1154-E)

11:30 AM – 12:30 PM Alpha-Synuclein aggregation and phosphorylation: Detection in cultured cells with AlphaLISA SureFire Ultra (1159-E)

11:30 AM – 12:30 PM Evaluation of new Stop And Go Extraction -Tips for peptide purification and comparison with 2 commercial Solid Phase Extraction - Tips (1164-E)

11:30 AM – 12:30 PM A multiplex bead platform for protein profiling of exosomes by flow cytometry (1169-E)

11:30 AM – 12:30 PM Protein liposome binding using the FIDA technology: A new approach for membrane protein interactions (1174-E)

11:30 AM – 12:30 PM Development of high throughput automated LC/MS/MS bioanalytical assay utilizing acoustic and pipette based liquid handlers (1179-E)

11:30 AM – 12:30 PM Spotting the weakest binders (1184-E)

11:30 AM – 12:30 PM Automated Plasmid Purification for Polyketide Synthase Engineering (1189-E)

11:30 AM – 12:30 PM HUNT One Health Enabling human-animal health investigations by population-wide studies of metagenomic data (1194-E)

11:30 AM – 12:30 PM Adaptive voltage protocols increase precision of voltage-gated ion channel measurements on high-throughput automated patch clamp platforms (1199-E)

11:30 AM – 12:30 PM Application of a novel in vitro drug distribution profiling assay in drug discovery projects. (1204-E)

11:30 AM – 12:30 PM Title: Automated passaging, feeding and plating on glass of gene-edited human inducible pluripotent stem cells for high-throughput 3D live cell microscopy pipeline. (1209-E)

11:30 AM – 12:30 PM High-throughput Drug Screening of Pilot Library for Potential Therapeutics against Leishmaniasis (1214-E)

11:30 AM – 12:30 PM Generalisable, automated execution of Design of Experiments for multifactorial media optimisation (1219-E)

11:30 AM – 12:30 PM Applying Deep Learning for High Content Image Analysis (1224-E)

11:30 AM – 12:30 PM PREDICT-96: High-Throughput Organ-on-Chip Microphysiological Platform for Drug Screening and Disease Modeling (1229-E)

11:30 AM – 12:30 PM Automated microfluidic droplet arrays for 3D personalized medicine (1234-E)

11:30 AM – 12:30 PM Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides (1239-E)

11:30 AM – 12:30 PM Data management solutions for samples are key for reproducible downstream analyses (1244-E)