Load-bearing biological structures must be capable of withstanding a wide variety of different mechanical loads. In particular, maize stems experience ever-changing loading environment from their own weight and the wind. The ability to withstand wind loading is dependent on the applied load from the wind, and the stem’s material and morphological characteristics. In this study, we investigate the morphology of physiological mature maize stems and determine which wind loading environments result in the most uniform maximum stresses along the stems. 945 fully mature, dried commercial hybrid maize stem specimens (82 hybrids, ~11 samples per hybrid) were subjected to two tests: (1) three-point bending tests to measure their flexural stiffness and strength, and (2) rind penetration tests to measure the cross-sectional morphology at each internode. The data collected in these tests were analyzed through an optimization algorithm to determine the theoretical loading profile that would produce the most consistent maximum bending stresses along the entire length of each specimen. It was found that maize stems are morphologically optimized for wind loading near the top of the stem. This seems to be consistent with the authors’ observations in field conditions; although border rows (plants at the border of the field) may experience loading along the full length of the stem, the majority of maize plants seem to only be loaded by the wind near the panicle at the top of their stem. It was also found that hybrids that are stronger tend to have more consistent levels of optimization, indicating the possibility that there exists a genetic component to the morphological optimization of maize stems to their wind loading environment.