Quantification of peptide/protein therapeutics in biological matrix, play a critical role in the drug discovery and development process. In this work, a novel triple quadrupole mass spectrometer is employed for quantitation of signature peptides derived from a digested monoclonal antibody or ADC. It provides a notable signal to noise improvement, enhanced CVs as well as improved LDR on the low end of range.
Achieve sub ng/mL LLOQ on mAbs, ADCs (antibody-drug conjugates) and cyclic peptides in complex biological matrices.
Obtain sub PPM LLOQ on large number of host cell proteins in a single analysis
Simplify method development when transitioning to microflow