Alongside the ability to formulate and deliver challenging poorly aqueous soluble APIs, liquid filled capsule based systems have a number of other advantages. Lipid based formulations can be formulated and manufacture in soft gel capsules or hard capsule shells. When developing a liquid filled hard capsule, capsule selection is fundamental and needs to be assessed early on the process, with a view to scale up to be performed.When enhancing bioavailability with lipid based systems, a number of oils and surfactants are employed and often these materials are of low viscosity. This presentation focuses on the processing of such oils and scale up considerations.
Explore the solubility of a range of current available dosage forms
Understand the challenges in developing enabling formulations for drug compounds with low solubility
Define the steps involved in processing liquid filled products
Understand the capsule selection process
Understand the challenges in processing of low viscosity oils