Characterization of Extractables and Leachables (E&Ls) is an important aspect of product quality in fields including pharmaceuticals, medical devices and food contact materials. A major concern regarding the accuracy of E&L studies is quantitative error due to response factor (RF) variation. In this study, a Multidetector approach using the combined strengths of triple detection liquid chromatography mass spectrometry (LCMS) with ultraviolet (UV) and charged aerosol detection (CAD) as well as Gas Chromatography Mass Spectrometry (GCMS) with simultaneous Flame Ionization Detection (FID) will be presented. Data comparing the response factors for over 200 extractables by UV, MS, FID and CAD will be summarized. An approach reducing RF variation which increases quantitation accuracy through optimized detector and standard selection will also be discussed.
Evaluate the benefits of a Multidetector approach including the Agilent 6545 QTOF for untargeted analyses and how detector and standard selection can be used to improve surrogate standard quantitation accuracy
Learn about the response factor (RF) distributions for over 200 extractables on LCMS, GCMS, FID, UV and CAD, and how RF variation impacts analysis results in surrogate standard quantitation.
Explore how Agilent MassHunter Profinder and Profiler can be applied to aid untargeted analysis.