This talk addresses the significant issue for early-stage physchem property assessment around the low amount of available compound for physical in vitro screening.
We will present new application data how, by using The Solubility Company’s proprietary SPA™ technology, it is possible to determine high-quality physicochemical data of stable or metastable crystalline forms, salts or amorphous samples from only a fraction of solid compound. One milligram of sample enables 10-20 separate solubility measurements and properties such as logP/logD and pKa are derived.
The SPA™ technology can be used to generate crucial solubility data in various media including aqueous buffers, organic solvents, formulation vehicles and simulated or native biological fluids. This data is further used to assist in synthesis and solid form optimization, administration route and formulation selection for animal toxicology and clinical studies, processability assessment and by indicating potential pharmacokinetic liabilities of R&D compounds.
Join our talk to learn more about how your organization can gain early access to this crucial information, boosting the whole subsequent drug development process.
Undertand how solubility of stable or metastable crystalline forms, salts or amorphous samples can be determined using less than 100 µg of sample material.
Understand how a pH-dependent solubility profile can be generated from less than 1 mg of sample material.
Upon completion the participent will understand how derived properties such as logP, LogD and pKa from less than 1 mg of sample are obtained.