Post-doctoral associate University of Miami, Florida
Human gut microbiome has tremendous potential to impact our physiology and is one of the key modulator of health. Dysbiosis can shift the microbial equilibrium leading to chronic health diseases. Opioid use and abuse has been associated with dysbiotic microbial community. Our lab research has established the role of prescription opioids in modulating gut microbiome and metabolome, thereby enhancing the susceptibility to various infectious and non-infectious diseases such as sepsis, S. pneumoniae and C. difficile infections and even neurocognitive deficits associated with HIV infections. Opioid induced dysbiosis drives pro-inflammatory shift at gut mucosal surface, causing acute influx of neutrophils and other inflammatory immune agents leading to disruption of mucosal barrier, bacterial translocation to other organs thus contributing to opioid tolerance and opioid associated co-morbidities. Strategies to maintain microbial homeostasis including use of pre and pro-biotics have been successful in attenuating opioid associated co-morbidities and to improve pain-relieving efficacy of opioids.
understand the role of opioid drug use and abuse in modulating gut microbiome and metabolome.
understand the role of gut microbiome on host cellular functions
understand the therapeutic approaches to restore gut microbial homeostasis