Product Development Manager Colorcon, Inc. Harleysville, Pennsylvania
Presentation Description: Continuous manufacturing has momentum within the pharmaceutical industry due to the lower cost of development, technical transfer and manufacturing, as well as improving product quality and consistency. As material passes through the continuous feeder, constant shear forces between the feeder wall and screw can potentially lead to particle attrition, density changes and generation of electrostatic charges. These changes, in raw material properties, may inadvertently affect the content uniformity and compression characteristic of the tablets. In this study, powder flow and compression characteristics of StarTab®, directly-compressible starch, were analyzed before and after feeding through the continuous feeder. SEM and particle size characterization displayed no difference in particle morphology. Dynamic tap density measurement indicated a low Hauser ratio and no major changes in packing kinetics of pre- and post-fed StarTab. Further, low cohesive index and electrostatic charge densities suggested similar flow behavior and dissipation of electrostatic charges for pre- and post-fed StarTab.
Advance understanding of key characteristics of a directly compressible excipient
Discover the utility of advanced powder flow property characterization techniques and the utility for the continuous manufacturing process.
Understand the performance of directly compressible excipient in continuous feeder
Demonstrate that feeding process in continuous manufacturing does not impact StarTab