Graduate Student University of Mississippi University, Mississippi
Presentation Description: Fractional solubility (α) of a drug in a topical formulation is defined as the ratio of the concentration of drug in the formulation to the saturation solubility of the drug in the same formulation. In the current study, fractional solubility is used as a measure of the thermodynamic activity, one of the main driving forces that impact the release of drug from the topical formulations, and thereby the amount of drug that is available for permeation. Topical formulations undergo metamorphosis after application on the skin due to the evaporation of solvents, which dynamically changes the thermodynamic activity of the drug in the formulation overtime. The presentation will discuss theoretical concepts related to the influence of fractional solubility on permeation of drug from topical formulations and empirical data that illustrates the impact of changes in the fractional solubility of a model drug, metronidazole, during metamorphosis, on drug permeation from topical formulations.
Learn about the approaches that can be used to evaluate the fractional solubility during metamorphosis.
Understand the influence of fractional solubility on drug permeation from topical formulations.
Understand the impact of changes in the fractional solubility during metamorphosis of topical formulations on drug permeation.