Percutaneous drug absorption is a process which involves steps such as (i) dissolution and release of drug from the vehicle/formulation, (ii) partition of drug into the stratum corneum, (iii) diffusion of the solubilized drug across the stratum corneum, and (iv) penetration of drug into the layers of the skin. In addition to skin, several factors such as physicochemical properties of drug (lipophilicity, solubility, molecular weight, and hydrogen bonding) and characteristics of a formulation influence the permeation. Although several studies have evaluated the effect of formulation properties on transdermal permeation of drugs, the scientific data show that the research was limited to only one factor, such as concentration of drug, concentration of excipients, and formulation type. This presentation provides results from a study evaluating the impact of formulation properties (concentration of drug, physical state of the drug, mucoadhesive agents, and formulation type) on permeation of ibuprofen from semisolid formulations.
Understand the effect of formulation parameters on transdermal permeation of ibuprofen
Conduct permeation studies using flow through cells and Strat-M membrane
Define the effect of physical state of drug on permeation profile