Scientist Graz University of Technology Graz, Austria
Presentation Description: The performance of capsule-based dry powder inhalers depends on sufficient powder dispersion in the device. Detailed information about the air flow and carrier particle motion in an Aerolizer® inhaler was retrieved from fully-coupled computational fluid dynamics and discrete element method simulations. These dynamic profile simulations consider the flow-dependent capsule rotation in the device and incorporate measured patient air flow profiles. The particle trajectories as well as collisions of a polydisperse carrier powder were tracked in the simulations. Compared to simple constant flow rate simulations, our innovative dynamic profile simulations give a clearer picture of dispersion-relevant metrics, especially the peak collision forces, collision locations and residence time distributions. Our work shows how experimental data on inhalation profiles and capsule motion patterns can be incorporated into advanced computational device studies to better understand dispersion and delivery from an inhaler device.
understand the relevance of incorporating real inhalation profiles into device simulations.
understand how to discretize and incorporate inhalation profiles into existing constant-flow-rate simulations.
learn why certain dispersion metrics are more sensitive to transient inhalation profiles than others.