Presentation Description: Polymeric medical implants are promising drug-eluting devices for their ability to modulate drug release, easy fabrication, and biocompatibility. Utilization of such implants reduces the frequency of drug dosing resulting in improved patient compliance. The recent studies on extrusion have delved into the formulation of implants using thermoplastic polymers. 3D printing technology revolutionizes the way how such implants are designed, facilitating a personalized treatment approach. Fused Deposition Modeling requires pre-fabrication using hot-melt extrusion, imparting repeated thermal stress on polymers. For our work, we investigated thermoplastic extrusion, a single-step additive manufacturing technique, to print dynamic polymeric implants. We intended to remove the initial filament fabrication step to accelerate production and process efficiency. Polycaprolactone was employed to load ketoprofen as an anti-inflammatory drug, and drug delivery properties were investigated. Batch to batch variation, the feasibility of on-site implant manufacture and stability of actives were further evaluated to validate the viability of this technology.
This presentation elucidates the practicability of a single-step extrusion technique for on-site manufacturing of polymeric implants in terms of productivity, time efficiency, and excipients selection.
After attending the session, participants will be able to understand the advantages of extrusion-based principles and the significance of amalgamation of implants manufacturing with 3D-printing technology.
Upon completion of the session, attendees will recognize the challenges associated with thermal-based printing technologies and current limitations of characterization and scalability of 3D-printed products.