Presentation Description: Oral and injectable controlled release formulations are commonly used clinically to reduce dosing frequency, improve patient compliance and modulate the drug’s pharmacokinetic profile to maintain constant plasma concentration and avoid high Cmax. Unfortunately, the application of controlled release strategies in drug discovery is underutilized partially because of the lack of technical support and the time and resources it takes to build a reliable in vivo model. In this talk will discuss different strategies for oral and injectable controlled release formulations and technologies that can be applied in drug discovery to study the effect of continuous target engagement, assess the possibility of reduced dosing frequency, improve bioavailability and reduce Cmax effect. The challenges and promises for each controlled release (CR) technique used will be presented. Real life examples in preclinical animal studies include: • Polymer/lipid matrix based oral controlled release tablets • Thermogels for SC controlled release injections • Mini pumps
Understand the advantages of controlled release formulations of small molecules in drug discovery
Learn the drug delivery strategies, techniques and technologies used in making controlled release small molecules formulations to be dosed in preclinical animals.
Understand the challenges of applying some of the controlled release delivery formulations of small molecules in preclinical animals.