This work evaluates the fundamental properties and performance of a rationally-designed and chemically-defined series of surfactant excipients to better understand the mechanisms that drive surfactant stability. The dynamic surface tension of n-alkyl phenylalanine Jeffamine M1000 diamide surfactants (xFM1000 with x ranging from 8 to 18 carbons) demonstrated a marked shift in shape and speed of surface equilibration. Shorter carbon lengths had drawn out, gradual equilibrations, while longer carbon lengths had precipitous drops in surface tension after an incubation time. In a polyclonal IgG model of aggregation, the 14FM1000 differentiated itself from both longer and shorter carbon derivatives. The enhanced performance of the 14FM1000 coupled with its improved stability compared to standard technologies offers promise for its development and use for stabilizing biologic formulations in the liquid state.
Upon completion, participants will understand the drivers of surfactant behavior in formulation
Upon completion, participants will be able to describe the structure-function relationships for surfactants in solution.
Upon completion, participants will be able to evaluate the key mechanistic surfactant needs for their formulations, enabling more rational choice of formulation ingredients.