The blood-brain barrier (BBB) presents a major obstacle to effectively deliver therapeutics to the central nervous system (CNS). The intranasal route of administration is increasingly being used as a means to potentially bypass the BBB to deliver drugs directly to the CNS in a non-invasive manner. We have recently identified the likely anatomical pathways and mechanisms that potential neurotherapeutics utilize to reach the CNS and rapidly distribute after intranasal administration. A general overview of relevant anatomical and physiological factors governing intranasal delivery from the nasal passages to the CNS will be provided in this presentation. In addition, evidence of extracellular pathways associated with the olfactory and trigeminal nerves in delivery of drugs to the CNS after intranasal administration will be discussed. The potential involvement of cerebral perivascular spaces in widespread brain distribution after intranasal administration will also be shown along with a discussion of the limitations and future directions of this method of brain drug delivery.
identify relevant anatomical routes involved in delivery of drugs from the nasal passages to the brain.
understand physiological processes governing intranasal delivery of drugs to the brain.
discuss limitations of intranasal drug delivery to the brain.
explore ways to potentially enhance intranasal drug delivery to the brain.