Director, Translational Biosciences Department National Research Council of Canada Ottawa, Ontario, Canada
The presentation will introduce key concepts for antibody transport across the blood-brain barrier (BBB), including receptor-mediated transcytosis (RMT). BBB receptors engaged in RMT, their targeting antibodies as well as mechanisms of their trans-cellular trafficking. will be reviewed. The talk will then focus on examples of brain-targeting bi-specific antibodies, methods for quantifying their exposure in different brain compartments, and determining their PK-PD relationship. Finally, translation of findings from rodents to primates will be discussed.
Understand routes for delivery of antibodies/biologics across the blood-brain barrier
Understand the concept and mechanisms of receptor-mediated transcytosis, and identify which BBB receptors are engaged in this process
Describe general principles in designing and engineering BBB-crossing bi-specific antibodies for CNS diseases
Interpret different methods and approaches for quantifying antibodies in various CNS compartments, and evaluating their pharmacodynamic effects
Discuss translational requirements for bi-specific BBB-crossing antibodies for pre-clinical and clinical development