Biomarkers for detection of heart disease are of critical importance given the growing burden of cardiovascular complications around the world. The identification the immune system as a major driver of cardiovascular disease has shifted our understanding of the mechanisms of disease. This increased understanding of disease pathology has encouraged new therapeutic intervention strategies to treat patients and has also provided opportunities to identify novel biomarkers associated with disease progression. Using a cohort of 359 subjects with cardiovascular disease, we have identified a unique antibody profile that is associated with a decreased incidence of adverse cardiovascular outcomes. Identification and characterization of this antibody profile will be presented along with evaluation of subjects from retrospective and prospective cohorts, as well as molecular characterization of the antibodies and their target epitopes will be discussed.
Understand the current understanding of the role of the immune response in cardiovascular disease progression.
Discuss the current landscape of cardiovascular disease biomarkers
Discover unique antibody profiles that predict cardiovascular disease outcomes in patients.