Development of advanced biomanufacturing technologies: challenges, opportunities, and potential solutions. Data-rich enabling PAT method development and implementation for process control.
Introduce an innovative tool to determine Viable Cell density (VCD), apoptosis and aggregation in bioprocesses, based on dynamic imaging analysis.
Identify opportunities of process improvement and enhanced process understanding that are enabled by PAT and associated process analytics and modeling.
Understand the development and implementation of state-of-the-art dynamic imaging analysis to meassure VCD apoptosis and aggregation. Compare DIA with three traditional methods: Vicel, flow cytometry, and capacitance.