Effective treatment of CNS disorders requires that drugs reach therapeutic concentrations in the brain. However, drug delivery to the brain is highly restricted by the blood-brain barrier, a dynamic interface between the blood and brain that tightly controls what goes in and comes out of the brain. This presentation describes the anatomy and physiology of the blood-brain barrier and highlights its role in limiting brain drug delivery of small and large therapeutic drugs. The presentation will focus on current drug delivery strategies including a new approach involving a transport vehicle. Despite advances in brain drug delivery, overcoming the blood-brain barrier remains a unique challenge due to the complex nature of barrier function that changes with disease. Finally, emerging concepts in blood-brain barrier research are summarized and the barrier as a moving target for brain drug delivery is discussed.
Explain the anatomy and physiology of the blood-brain barrier in the context of brain drug delivery.
Describe current drug delivery strategies and their use for optimization of brain delivery of small and large molecule therapeutic drugs.
Describe emerging concepts in blood-brain barrier research.
Discuss blood-brain barrier function as a moving target during disease.