Attendees will receive a basic introduction to biomarkers for assessing the health of nerve and muscle so as to monitor progression of a variety of disorders and to assess the effect of therapy. These will include such established biomarkers as standard functional measures, electrophysiological tests, and molecular assays. However, newer approaches will also be reviewed including imaging modalities, such as magnetic resonance imaging and ultrasound techniques, and compositional measures, such as electrical impedance myography. In addition to reviewing these various biomarkers, their relative advantages and disadvantages will be reviewed. An effort will also be made to review the potential power and implementation of at-home assessment techniques. At the conclusion of this session, attendees should have a deeper understanding of the relative challenges and advantages of various biomarkers for monitoring therapeutic intervention in a wide range of neuromuscular disorders, including amyotrophic lateral sclerosis, muscular dystrophies, peripheral neuropathies, and spinal muscular atrophy.
Upon completion, participants will be able to identify established approaches for quantitatively assessing muscle and nerve health and the effect of therapy .
Upon completion, participants will be able to describe more recently developed innovative approaches for assessing muscle and nerve health and the effect of therapy.
Upon completion, paticipants will hold the tools to make better decisions for choosing neuromuscular biomarkers that will be most likely to capture a therapeutic effect.
Upon completion, participants will better understand approaches for remotely collecting data that reflect muscle and nerve health and the effect of therapy.