Track: Formulation and Delivery - Biomolecular - Formulation - Other
Category: Late Breaking Poster Abstract
Gentle Drying for Thermosensitive Active Pharmaceutical Ingredients
Purpose: To preserve the active ingredient and microencapsulating it to prevent the loss of in viability after processing and during storage due to stress related to temperature, oxygen, moisture, water, activity, pressure and PH. Methods: Electostatic spray drying is a continuous process.The electrostatic charge increases the diffusivity of the water at the surface, reducing the thermal energy needed to dry. Results: To show that Electrostatic spray drying uses less heat and preserves the active pharmaceutical ingredients, while increasing the shelf life of the product. Conclusion: By applying the electrostatic charge on the droplets, polar solvents are driven to the outside of the droplets and the pharmaceutical ingredient or probiotics are driven to the inside. This layer protects the ingredients from thermal stresses. References:  A. Ziaee, A.B. Albradarin, L. Padrela, T. Femmer, E. O'Reilly, G. Walker, Spray drying of pharmaceuticals and biopharmaceuticals: Crirical parameters and experimental process optimization approaches, European Journal of Pharmaceutical Sciences, 127 (2019) 300-318.  J. Perdana, L. Bereschenko, M.B. Fox, J.H. Kuperus, M. Kleerebezem, R. M. Boom, M. A.I Schutyser, Deshydration and thermal inactivation of Lactobacillus plantarum WCFS1: Comparison single droplet drying to spray and freeze drying, Food Research International, 54 (2013) 1351-1359.  A. Wang, J. Lin, and Q. Zhong, ‘Probiotic powders prepared by mixing suspension of Lactobacillus salivarius NRRL B-30514 and spray-dried lactose: Physical and microbiological properties’, Food Res. Int., vol. 127, p. 108706, Jan. 2020, doi: 10.1016/j.foodres.2019.108706.  G. Broeckx, D. Vandenheuvel, I. J. J. Claes, S. Lebeer, and F. Kiekens, ‘Drying techniques of probiotic bacteria as an important step towards the development of novel pharmabiotics’, Int. J. Pharm., vol. 505, no. 1, pp. 303–318, May 2016, doi: 10.1016/j.ijpharm.2016.04.002.