Track: Discovery and Basic Research - Medicinal Chemistry - Small Molecules
Category: Late Breaking Poster Abstract
Evaluating the PTP1B Inhibitory Potential of Dithiocarbamates
Purpose: Evaluation of thiocarbamate scaffold for its PTP1B inhibitory activity. Methods: Various molecules were synthesized using TMTD as substrate. TMTD was reacted with different Grignard reagents and lithium compounds at various reaction conditions to yield ditiocarmate analogs. Synthesised molecules were tested for their PTP inhibitory activity by a hydrolysis assay using pNP as substrate. The docking studies for the synthesized molecules were conducted using PyRx and visualized using Discovery studio visualizer. Results: Various alkyl and aryl ditiocarbamates were synthesised and the variations in their activity depending upon differences in their structures were observed. Conclusion: Effects of structural variability of dithiocarbamates on PTP1B inhibitory activity were studied.
(1) Kerru, N.; Singh-Pillay, A.; Awolade, P.; Singh, P. Current Anti-Diabetic Agents and Their Molecular Targets: A Review. Eur. J. Med. Chem. 2018, 152, 436–488. https://doi.org/10.1016/j.ejmech.2018.04.061.
(2) Verma, M.; Gupta, S. J.; Chaudhary, A.; Garg, V. K. Protein Tyrosine Phosphatase 1B Inhibitors as Antidiabetic Agents – A Brief Review. Bioorganic Chem. 2017, 70, 267–283. https://doi.org/10.1016/j.bioorg.2016.12.004.
(3) Grunwell, J. R. Reaction of Grignard Reagents with Tetramethylthiuram Disulfide [Yielding Dithiocarbamates]. J. Org. Chem. 1970, 35 (5), 1500– 1501. https://doi.org/10.1021/jo00830a052.