Track: Discovery and Basic Research - Pharmaceutics - Drug Delivery Novel Systems
Category: Poster Abstract
Monoglyceride-Based Thermally Sensitive Drug Delivery System
Purpose: The development of a thermally sensitive drug delivery system via a lipid matrix is a novel alternative for a drug delivery. Many stimuli-response drug delivery systems incorporate the use of polymers. Monoglycerides, such as glyceryl monooleate (GMO) and glyceryl monostearate (GMS), are self-assembling amphiphilic molecules that form a variety of crystalline structures with useful mechanical properties of special interest in drug delivery. Methods: A lipid matrix mixture of 75:25 GMS:GMO was prepared by a fusion method and analyzed using a differential scanning calorimeter (DSC1, Mettler Toledo). Nifedipine was added at 5% and 10% w/w as a model drug to analyze the loading capacity and to determine the physical properties of the drug-loaded lipid matrix. Results: The melting point of the lipid matrix as well as drug-loaded lipid matrix decreased consistently between the 1st and 2nd analysis of the DSC, but remained constant after the 2nd analysis. This indicates a change in polymorph between the initial lipid matrix and recrystallization. A consistent polymorph is favored for drug delivery systems. The melting point of pure nifedipine was found to be around 175°C. DSC of samples with 5% and 10% nifedipine showed no nifedipine melting point peak around 175°C, indicating that nifedipine is either dissolved or in an amorphous state in the lipid matrix. Conclusion: In conclusion, a binary blend of GMS and GMO, forming a lipid matrix, has the capability to act as a safe stimuli-response drug delivery system.