Synchrotron X-ray Pair Distribution Function (SXPDF) techniques provide information on the atom-atom distances in amorphous materials and dispersions. Not all amorphous materials are equivalent, and the PDF patterns can be used to compare the sameness of materials prepared in different ways (e.g. spray drying and melt extrusion). SXPDF can also detect neighboring drug molecules in a drug-polymer dispersion. If present, the dispersion is more likely to crystallize as compared to dispersions where no drug domains are detected. Finally, SXPDF can be used to analyze amorphous materials and dispersions as they are being made. Drops of the solutions are suspended in a levitator and synchrotron data are collected as the droplets evaporate, allowing a look (at very small scales) into what is happening during a spray-drying process. This presentation will introduce the viewer to the concept of SXPDF and present the latest advancements.
Upon completion, the participant will be able to understand the power of synchrotron methods and how to access this technology
Upon completion, the participant will be able to differentiate between intermolecular and intramolecular atom-atom interactions in a dispersion, and apply this knowledge to predicting the stability of a dispersion
Upon completion, the participant will be able to bridge a gap in the current drug development process by understanding how better to control the solid form in a formulation