US Food and Drug Administration
Silver Spring, Maryland
Dr. Volpe received a BA in biology from Canisius College in Buffalo, NY. Then a master’s and doctorate from the University of Buffalo. This was followed by a postdoctoral fellowship at the Hipple Cancer Research Center in Dayton, OH working on an NCI-funded project looking at the bone marrow toxicity of anticancer and antiviral drugs.
Dr. Volpe joined the FDA to continue studies on drug-induced bone marrow toxicity with human, canine and murine models. She then changed her research focus to work on the Caco-2 cell permeability model, BCS classifications, and drug stability studies. This was followed another research to work on drug metabolism and transporter projects. In the Division of Applied Regulatory Science (DARS), Dr. Volpe is the lead researcher in the drug metabolism, transporter and drug-drug interaction group.
Dr. Volpe has been involved in a number of studies including in vitro drug metabolism, P-gp efflux and permeability assays in Caco-2 cells, binding affinities of opioid drugs, and hepatotoxicity. She also provides scientific expertise to reviewers as a member of DARS’ multi-disciplinary teams on drug permeability, metabolism and transport.