Texas Tech University Health Sciences Center
Dr. Luca Cucullo; Associate Professor; Dept. of Pharmaceutical Sciences; Texas Tech University Health Sciences Center.
I have over 18 years of research experience in advanced cerebrovascular modeling in vitro for toxicological, pharmacokinetic and pharmacodynamic studies of drugs targeting the brain as well as cell to cell interactions with the innate immune system. I also have an extensive expertise in the field of neuropharmacology, toxicology and neurological diseases related to blood-brain barrier impairment. My research interests are largely focused on translational neuroscience and comprise the study of cross interactions between the cellular elements of the neurovascular unit; the development of multidrug resistance at the BBB; biomarkers of BBB disruption; environmental and cellular modulation of BBB functions and their relevance to the onset of neuroinflammation, stroke/ischemia, and the pathogenesis of secondary brain injury. In the past 10 years my research focus has been revolved on investigating the pathophysiology of tobacco smoke and e-cigarette toxicity at the neurovascular unit. The study encompasses both identification of potential prodromal factors for the pathogenesis and progression of cerebrovascular impairment and brain disorders as well as potential countermeasures including antioxidant treatments and promoters on the innate antioxidative response system.