Theory posits that dissociation is a response to shame (Freyd, DePrince, & Gleaves, 2007). Both shame and dissociation have been theoretically and empirically implicated in trauma and its sequelae, however, the strength of the relationship has yet to be assessed. Dissociation, or experiences of spacing out that may interfere with a person’s ability to experience emotions and be aware of external surroundings, and shame have both shown to be impacted by traumatic experiences. Moreover, trait shame and dissociation are considered risk factors for a variety of psychopathologies. This meta-analysis analyzes the magnitude of the association between the two phenomena, and investigates to what extent gender, trauma exposure, and psychiatric comorbidities influence the correlation, given their independent relationships with shame and dissociation. The following six databases were used for the meta-analysis: Cochrane, CINAHL, PubMed, ProQuest, Medline, and Academic Search Complete. The initial search found 151,844 articles. Duplicate articles were removed and the remaining articles were excluded based on title, abstract, and finally a full text screen yielding 34 articles for analysis. Articles were reviewed by at least two of three independent reviewers 34 articles remained for analysis. Results of this meta-analysis indicate that shame and dissociation are moderately correlated (r = 0.42, p < .0001). Despite this association, there were no studies in our meta analysis that utilized experimental design to examine the relationship between shame and dissociation. Future research should focus on experimental research examining if shame induces dissociation.