Category: Clinical Sciences/Health Conditions
Objectives: Analysis of muscle cross-sectional area, a measure for sarcopenia, has been associated with survival. The pectoralis muscle may be a more accessible target in lung cancer patients, but it is not known if this correlates with iliopsoas cross-sectional area. We attempted to determine if these muscles could be seen, examine the cross-sectional area of the two muscle groups, and evaluate for any changes over the treatment period.
Design: Charts were reviewed in 44 subjects who underwent surgical treatment. The cross-sectional area of the pectoralis and iliopsoas muscles bilaterally were measured manually at diagnosis by two different researchers, and the pectoralis was measured at 6 months and 12 months. Follow-up iliopsoas data was not available.
Results: Of the 44 subjects, 13 had a complete set of imaging. The mean age was 66 years old and the mean BMI was 28.72. There were 8 females and 5 males. 12 out of 13 were Caucasian. 12 out of 13 were stage T1 or T2. 12 out of 13 had undergone lobectomy. 10 out of 13 were at ECOG performance grade 0 at diagnosis. 4 out of 13 had postoperative events. The mean iliopsoas area at diagnosis was 8.17cm.2 The mean pectoralis area at diagnosis was 14.5cm.2 The mean pectoralis area at 6 months was 13.9cm2. The mean pectoralis area at 12 months was 14.5cm.2 8 out of the 13 subjects had a decrease in mean pectoralis area at 6 months and 6 subjects had a decrease at 12 months, but neither were statistically significant.
Conclusions: There was no significant decrease in cross-sectional area of the pectoralis over the lung cancer treatment period. Imaging of the iliopsoas was only available at diagnosis. No significant change could be due to the initial high performance status of our sample, small sample size, or that sarcopenia occurs comorbidly with presentation.
Jennifer Baima– Assistant Professor, University of Massachusetts Medical School
Elke Schipani– Medical Student, University of Massachusetts Medical School
Karl Uy– Chief, Division of Thoracic Surgery, Umass Medical School
Wasih Kamran– medical student, University of Massachusetts Medical School
Lacey McIntosh– Director, Oncologic Imaging, University of Massachusetts
John Varlotto– Professor of Radiation Oncology, University of Massachusetts Medical school
Maggie Powers– nurse practitioner, Universsity of Massachusetts Medical System
Isabel Emmerick– data quality manager, University of Massachusetts Medical School
Mathew Most– Chief, Division of Orthopedic Oncology, UMassMemorial Heath Care
Mark Maxfield– Assistant Professor of Thoracic Surgery, University of Massachusetts Medical System
Feiran Lou– Assistant Professor of Thoracic Surgery, University of Massachusetts Medical System
William Walsh– Professor of Hematology and Oncology, University of Massachusetts Medical System