Objectives: Objective of the PAST TRIAL is to determine the effectiveness of single dose, i). Peripheral derived stem cell therapy for the treatment of Knee OA; ii). Adipose tissue derived stem cell (Micro fat transfer) therapy for the treatment of Knee OA. This trial is also to compare the outcome between two groups.
Design: Randomized clinical trial
Results: During recruitment, mean age of respondents of PBSC and ATSC group was 63.6±4.2 and 63.1±3.1 year respectively. Female gender was predominant in both group. Mean BMI was estimated as 28.7±2.0 in PBSC and 29.1±1.8 in ATSC group. Pain was measured by using visual analogue scale (VAS) and the mean pain score was 6.4±1.2 and 6.3±1.3 among PBSC and ATSC group respectively at VAS 0-10 centimeter scale. The mean cartilage thickness among PBSC and ATSC group was 1.8±0.3 mm and 1.9±0.2 mm respectively.
The premature results show both cell based therapies are effective and safe for patients with OA knee. However, among both approaches, ATSC is slightly superior to PBSC on VAS and WOMAC scale at 6 months. Cartilage thickness was not changed a lot in either group.
Moshiur Khasru– Associate Professor, Bangabandhu Sheikh mujib Medical University
Tangila Marzen– Assistant Surgeon, Dhaka Medical College
AKM Salek– Professor, Bangabandhu Shiekh Mujib Medical University
Khandoker Mohammad Hossain– Major, Bangladesh Army
Md. Ali Emran– Associate Professor, Bangabandhu Sheikh Mujib Medical University
Md. Tariqul Islam– Associate Professor, Bangabandhu Sheikh Mujib Medical University
Md. Nuruzzaman Khandaker– Assistant Professor, Bangabandhu Sheikh Mujib Medical University
Taslim Uddin– professor, Bangabandhu Shiekh Mujib Medical University