To assess the efficacy of intra-articular injection of Botulinum toxin A (BoNT/A) for the treatment of chronic refractory knee pain due to osteoarthritis.
Data Sources: The researchers searched PubMed, Google Scholar, Ovid MEDLINE(R), Ovid EMBASE, Ovid MEDLINE (R) In-Process and Other Non-Indexed Citations through May 30th, 2019.
Trial selection: Clinical double-blinded randomized controlled trials that evaluated BoNT/A intra-articular injection in patients with chronic refractory knee pain due to osteoarthritis
Data Extraction: Two independent reviewers conducted data extraction.
The results of this meta-analysis indicate that, in patients with refractory osteoarthritic knee pain, intra-articular low dose (100u) Botulinum Toxin A treatment results in mild pain relief with decreased VAS and WOMAC total scores over 12 weeks.
Derek Schirmer– Medical Student, Kansas City University of Medicine and Biosciences
Stephanie Modert– Medical Student, Kansas City University of Medicine and Biosciences
David Sherwood– Resident Physician, Kansas University Medical Center
Barth Wright– Chair of Anatomy Department, Kansas City University of Medicine and Biosciences