OR-2682 - Personal History Of Febrile Seizure Increases Risk Of Measles-mumps-rubella Vaccine Attributable Seizure

Shirley V Wang, Lily Bessette, Kristina Stefanini, Bruce Fireman, Ned Lewis, Jonathan Duffy, Michael McNeill, Seanna Vine, Krista Huybrechts and Martin Kulldorff

The finding of a small increased risk of febrile seizure in the 7-10 days following measles-mumps-rubella (MMR) vaccination in children 11-22 months of age has been replicated in multiple studies using different data sources (attributable risk ~3-4 per 10,000 vaccinated children). The benefit of protection from measles, mumps, and rubella outweighs the potential harm from a febrile seizure. Nevertheless, there may be subgroups of children for whom the risk of MMR-attributable seizure is not small. The variation in risk of MMR vaccine-attributable seizure observed in this study could be useful for informing clinical strategies to prevent febrile seizure after vaccination in high-risk children.