Poster Only Presentation
Concurrent Session 1C - DOHaD
Introduction: Iron deficiency (ID) is the leading single-nutrient deficiency in the world. Anemia is a common outcome of ID that affects half of pregnancies worldwide with serious consequences for child development. The correlations between biomarkers of iron status and anemia in the mother during pregnancy and neonatal/infant iron status and anemia is unclear. This systematic review evaluated studies comparing biomarkers of anemia and iron status in pregnant women and their infants.
Methods: A comprehensive search of four electronic databases was conducted (MEDLINE, EMBASE, CINAHL, Web of Science) from inception to May 2018 for studies comparing biomarkers of iron status and anemia between women with uncomplicated pregnancies and their children. Results were described narratively, and meta-analyses of correlation coefficients were conducted under random-effects models. The Newcastle-Ottawa Scale of quality assessment was used to assess study risk of bias.
Results: From 6,044 studies initially screened, 65 were included with sample sizes ranging from 28 to 3,981. Twenty three studies were conducted in Asia, 17 in Europe, 9 in North America, 7 in Africa, 6 in South America, 2 in Australia and Oceania. Pooled correlation coefficients for biomarkers of iron status in mothers and corresponding measures in newborns/infants were 0.30 (serum/plasma iron; n=23 studies), 0.13 (ferritin; n=32 studies), 0.20 (transferrin saturation; n=9 studies), 0.16 (total iron binding capacity; n=8 studies), 0.09 (transferrin; n=3 studies), 0.42 (transferrin; n=4 studies). Pooled correlation coefficients for biomarkers of anemia in mothers and corresponding measures in newborns/infants were 0.15 (haemoglobin; n=31 studies), 0.15 (haematocrit; n=10 studies), 0.22 (mean cell volume; n=6 studies), 0.25 (mean corpuscular haemoglobin; n=5 studies).
Conclusion: Biomarkers of iron status and anemia in mothers correlate poorly with those in newborns/infants. These results suggest cord blood should be routinely collected and assessed for iron biomarkers, and inform the need for better indices of fetal iron status.