Oral or Poster Presentation
Concurrent Session 1C - DOHaD
Introduction: LGA infants are at higher risk for childhood overweight and obesity. We aimed to compare weight trajectories in the first 2 years of life between large- and appropriate-for-gestational-age (LGA, AGA) infants and to evaluate whether breastfeeding and maternal pre-pregnancy body mass index (BMI) influence infantsâ€™ growth pattern.
Methods: The study included 127 LGA and 1382 AGA infants from the 3D Birth Cohort. Infantsâ€™ weight was measured at 3, 12 and 24 months. Breastfeeding was evaluated at 3 and 12 months and was stratified by duration (<6 or â‰Ą6 months). Multivariate mixed models were performed to evaluate the association between infantsâ€™ weight status (LGA or AGA), weight trajectories and the interaction with breastfeeding and maternal pre-pregnancy BMI.
Results: Pre-pregnancy obesity (BMI>30kg/m2) in mothers of LGA infants was 19.8% compared to 11.4% in mothers of AGA infants (p<0.01). More than 60% of LGA and AGA infants were breastfed more than 6 months (p=0.51). From birth to 2 years, 8.3% LGA and 30.7% AGA infants had an excessive weight gain (p<0.0001). LGA were consistently bigger than AGA even after adjusting for ethnicity and infant sex (p<0.0001). At 2 years, the weight difference between LGA and AGA infants was lower in infants of obese mothers (0.42 [95% CI 0.12â€“0.73]) g compared to infants of non-obese mothers (0.88 [0.72â€“1.05])g (test for interaction, p=0.01). Breastfeeding did not modulate growth differently in LGA and AGA infants (test for interaction, p=0.55). However, infants breastfed <6 months gained more weight at 1 and 2 years compared to those breastfed â‰Ą6 months (p<0.05).
Conclusion: LGA infants aged of 2 remained heavier than AGA infants. Breastfeeding less than 6 months was associated with higher weight in the first 2 years of life. Moreover, pre-pregnancy maternal obesity may modulate growth patterns differently in LGA and AGA infants.