Introduction: Introduction: Preeclampsia is a major cause of maternal and neonatal morbidity and mortality. A severe form of preeclampsia is the HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelets) syndrome. Cytokines play a key role in the pathogenesis of preeclampsia. It is unknown if differences in levels of cytokines exist in preeclampsia and HELLP syndrome.
Objective: To estimate levels of pro-inflammatory and anti-inflammatory cytokines in preeclampsia and HELLP.
Mothers with preeclampsia (n=38), HELLP syndrome (n=35 and normotensive pregnancies (n=37) were, recruited from the Obstetrics Department at the Foothills Medical Centre . Levels of pro-inflammatory cytokines IFN-γ, 1L-1β, 1L-6, IL-8, TNF-α and anti-inflammatory cytokine IL-10 were measured by enzyme-linked immunosorbent assays . Exclusion criteria included maternal fever, chorioamnionitis, multiple gestation, diabetes mellitus, maternal renal, cardiovascular, endocrine or auto-immune disease, chronic hypertension, substance abuse, TORCH infections, PROM (premature rupture of membranes), and PPROM (preterm premature rupture of membranes), congenital malformations, multiple pregnancy. Kruskal-Wallis test was used for statistical analysis as appropriate. P-value of <0.05 was considered significant. Bonferroni correction was used post hoc for multiple comparisons.
Please see tables.
1. Compared to mothers with preeclampsia, we found higher levels of IL-10, IL8, IFN-γ in mothers with HELLP syndrome.
2. Our data suggests HELLP and preeclampsia have distinct cytokine profiles.
3. These cytokines may be useful for early detection of HELLP in mothers with preeclampsia.
Kamran Yusuf– Associate Professor, Department of Paediatrics University of Calgary